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Pevarello, J. Changes in absorbance Model. Wang, Y. Yang, C. Ying, W. Li, H. Ruan, X. Zhu, Y. You, Y. Han, R. Chen, were recorded at nm for 5 min. Values were expressed as units Y. Wang, M. Li, Neuropharmacology 52 — Helal, M. Sanner, C. Cooper, T. Gant, M. Adam, J. Lucas, Z. Kang, 6. All samples were assayed in duplicate. Kupchinsky, M. Ahlijanian, B.
Tate, F. Menniti, K. Kelly, M. Peterson, Bioorg. GSH-Px activity was expressed as units per gram protein. Doria, C. Passarotti, R. Sala, R. Magrini, P. Sberze, M. Tibolla, R. Cesarini, G. Arcari, R. Castello, D. Toti, Il Farmaco Ed. Total protein determinations [36] D. Slee, M. Lanier, B. Vong, Y. Chen, X. Zhang, E. Lin, M. Moorjani, P. Castro, J. Laria, US Patent 20,,,, 06 November Total protein concentration of brain homogenates was deter- [37] Y.
Sugihara, Y. Kawakita, US Patent 20,,,, 30 October Khokara, O. Prakash, Synthesis of 1- substituted phenyl 3- Bovine serum albumin BSA was used as the standard.
Statistical analysis [39] S. Frank, W. Schmidt, Exp. Brain Res. Sanberg, M. Giordano, M. Bunsey, A. Norman, Behav. E of the [41] M. Correa, A. Wisniecki, A. Betz, D. Dobson, M. For a statistical analysis of the data, group means were J. Salamone, Behav. Sukalovic, D. Andric, G. Roglic, S. Kostic-Rajacic, A. Schrattenholz, V. The post hoc Bonferroni multiple comparison test was [43] E. Homan, E. Kroodsma, S. Copinga, L. Unelius, N. Mohell, H. Grol, Bioorg.
Tepper, D. Dijkstra, G. Damsma, H. Wikstrom, T. Akunne, T. Heffner, S. Glase, L. Wise, J. Teeter, C. DuRand, Drug Des. Simpson, J. Ballesteros, V. Chiappa, J. Chen, M. Suehiro, D. Hartman, Acknowledgements T. Godel, L. Snyder, T. Sakmar, J. Javitch, Mol. Drechsel, M. Patel, Free Radic. Med 44 — The authors are grateful to Head, Sophisticated Analytical [48] T. Dawson, V. Dawson, Nat. Maan-Yuh, H. Low-Tone, Free Radic. Shivkumar, V. Ravindranath, J. Polydoro, N. Noemia, M. Lima, F.
Caldana, D. Laranja, E. Bromberg, R. Roesler, J. Quevedo, J. Moreira, F. Dal-Pizzol, Phar- References macol. Naidu, A. Kulkarni, Br. Abou-Sleiman, M. Muqit, N. Wood, Nat. Elkashef, R. Wyatt, Schizophr. Yao, R. Reddy, L. McElhinny, D. Fahn, S. Przedborski, in: L. Rowland Ed. Vairetti, A. Ferrigno, P. Canonico, A. Battaglia, F.
Berte, P. Richelmi, Eur. Dauer, S. Przedborski, Neuron 39 — Olanow, Neurology 47 S—S We have also attempted to produce 4 in a somewhat shorter Compounds 13 and 22 were also tested against human salivary way from b-D-glucosyl urea and PhNCO. Using ited inhibition in the low millimolar range IC50 Introduction of in the reaction mixture. When 6 was reacted with 1 equiv of the highly polar sugar moieties resulted in weak binding. Urea 7 was also formed when D-glucopyranosyl and the aromatic parts of the inhibitors proved 6 and 1 equiv of PhNH2 were reacted in boiling toluene.
Finally, to be optimal in the acyl urea series. OAc mined with a Perkin—Elmer polarimeter at rt. Microanalyses were performed on a Carlo-Erba analyser R2 Type For column chromatography Kieselgel 60 Merck, particle size O O 0. Mp: Scheme 2. Optical rotations were deter- C-6 , Calcd for C22H27N3O11 Found: C, A catalytic amount of AcCl was added C-5 , The reaction was monitored by for C28H31N3O11 ESIMS: 3. The mixture was stirred at rt under nitro- ane. The organic layer was separated, EtOAc—hexane the mixture was diluted with water 5 mL , and dried and the solvent was evaporated.
Found: C, to the solution in a catalytic amount. The reaction mixture was Filtration and removal of the solvent resulted in acetyl-b-D-glucopyranosyl per-O-acetyl-b-D- the corresponding deacetylated sugar derivatives.
The biuret 12 mg, 0. NMR D2O : d ppm 4. Calcd for C14H25N3O12 Found: HGlc , 5. Calcd for C30H41N3O20 Found: C, 3. Then 5. The residue was 5a-Xyl , 3. Calcd for C27H37N3O18 Calcd for C30H40N2O20 6 , Calcd for C50H48N2O20 Acknowledgements 3. This work was supported by the EU Marie Cur- urea 21 mg, 0. The authors thank Professor K. NMR D2O : d ppm
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